Too much LDL cholesterol in the blood is a major risk factor for heart disease, heart attack and stroke to the to the buildup of plaque the walls of arteries the walls of arteries. Up to 30 million people worldwide take a class of drugs called statins to lower their cholesterol levels within the recommended healthy limits.
The protein, called PCSK9 disrupts molecule molecule key called low-density lipoprotein receptor, or LDLR. This molecule , which is produced and secreted in the liver, the latch on the LDL receptor. This binding, however, triggers a chain of biochemical reactions that leads to the destruction of the LDL receptor. With fewer receptors available, leaving more of the so-called ‘bad’cholesterol in the blood. Horton said new findings new findings, ‘t acts mainly as a secreted protein to to the reduction of LDL – receptors. ‘So close to the protein’s activity should block the blood successful in reducing plasma cholesterol levels,’he said. Continue reading